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Finding new molecular pathways and strategies modulating lipolysis in adipocytes is an attractive goal of the current research.
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Hence, interfaces are the key spots for lipase biocatalysis and an appropriate site for modulating lipolysis.
On the other hand, the transcription factor, FoxO1, was found to modulate lipolysis through its regulation of ATGL expression [37].
In response to fasting, FGF21 can regulate lipolysis in adipocytes [ 12].
Adipocytes are the primary target of FGF21, where it increases glucose uptake, modulates lipolysis, enhances mitochondrial oxidative capacity, enhances PPARγ activity, and promotes browning of white adipose tissue.
Dietary carbohydrate modulates lipolysis, de novo lipogenesis and effects the interaction between dietary fat intake and plasma saturated fatty acid levels.
Although UAG treatment of Ghsr deficient mice primarily affects lipogenesis, we considered that the lipolytic pathway may also be modulated, since UAG affects lipolysis in vitro [12].
Oestrogen treatment in mice is known to increase lipolysis in abdominal fat cells and to modulate leptin responsiveness in several ways.
Perilipins also regulate lipolysis by modulating the access of hormone sensitive lipases (HSL) to the surface of lipid droplet [ 47].
To investigate whether ATGL is also involved in LD lipolysis in other human cell types, Smirnova et al. [ 18] modulated the level of the enzyme in HeLa cells by RNA interference or by overexpression of wild-type and a mutated form of GFP (green fluorescent protein -labelled ATGL resprotein -labelled
Moreover, GA feeding induced lipolysis in both paraepididymal and perirenal adipose tissues.
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