Sentence examples for modulating ligands to from inspiring English sources

This involves, at least in part, the binding of signal modulating ligands to the extracellular domain.

However, as IgFLN domains can form domain-pairs and so regulate neighbouring domains [36] the Δ19 21 mutation could also exert its effects by modulating ligand binding to adjacent IgFLN domains.

Diverse stereochemical mechanisms for modulating ligand affinity through intersubunit interactions have been revealed from studies of three distinct hemoglobin assemblages.

We expect that the force-induced deformation of pyranose rings reported here plays an important role in accommodating mechanical stresses and modulating ligand binding in biological systems.

These findings are consistent with our previous work (see Asawakarn et al. [29]) that indicated that the membrane dipole potential plays an important role in modulating ligand-membrane interactions.

Thus, receptor dimerization of ErbB1 with ErbB2 may not only prolong signaling by modulating ligand binding properties as discussed earlier, but also by altering receptor trafficking.

It is unlikely that the generic phospholipids we used to assay binding are the functionally critical ones for Jagged-1, and indeed an earlier genetic study implicated glycosphingolipids in modulating ligand activity in Drosophila (Hamel et al., 2010).

Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.

Wnts are subject to negative and positive regulation by a wide range on effectors that act either intracellularly to modulate components of the signal transduction machinery, or extracellularly to modulate ligand receptor interactions.

However based on current knowledge it cannot be completely ruled out that they are involved in the modification of the LARGE glycan repeat itself to modulate ligand binding.

It has recently been demonstrated that selective ligands at pairs of GPCRs that heterodimerize have the potential to modulate ligand effects at the partner GPCR via allosterism (see [ 25] for review).