CHD7 can modulate genes in either the positive or negative direction, although negative regulation appears to be the more direct effect of CHD7 binding.
The numbers of commonly modulated genes in the 4 human hepatocyte donors varied from 9 to 71% depending on PPAR agonist and concentration (Table 2).
The significant increase in the proportion of developmentally modulated genes in D. sechellia is striking.
All the significantly modulated genes in any of the pair wise comparison of interest are listed in Additional file 1.
Notably, the core modulated genes in the ERBB2-alone group were enriched in highly similar GO terms (data not shown).
The CysR coregulated genes SMU_984 and SMU_609 were 2 of the 3 strongest modulated genes in the transcriptome analysis of an exponentially growing pknB deletion strain [ 103].
Interestingly, the number of transcriptionally modulated genes in sophorose (726) was greater than that in cellulose (359), when both were compared to glucose.
In order to evaluate the differences in cell cycle that maybe caused by parthenocarpic development, we also checked differentially modulated genes in parthenocarpic fruit set with respect to normal fruit set (variables eTIME RP75/59 and eRP75/59vsUC82) (Table 4).
With miR-107 also possessing the capacity to regulate E2F1 expression, the proportion of observed changes that can be attributed to primary and secondary miR-107 function were also investigated, explaining 87% of bidirectionally modulated genes in both cell types.
Recently, miR-140 has emerged as being implicated in OA by modulating genes involved in the pathogenesis of this disease.
Moreover, fibroblasts activated by miR-9-5p althe tumorumor behavior, modulating genes involved in cell motility and extracellular matrix (ECM) modeling [43].
