Restriction-modification (RM) systems appear to play key roles in modulating gene flow among bacteria and archaea.
Moreover, each newly discovered T-SCE modulating gene offers yet another opportunity to test the hypothetical dependence of replicative senescence on T-SCE rate [ 12, 15- 17].
As previously assumed [ 2], non-essential and essential toxicity-modulating gene products were present in the same biological networks.
Our data set, being unique in authentic expression design, uncovered niche-modulated and niche-modulating genes capable of controlling homing, expansion and angiogenesis.
The expression patterns, activities and roles in pathogenesis of these interferon-modulating genes during MPV infection remain to be established.
Our poxvirus-human microarray was able to detect the viral transcripts encoding the predicted MPXV interferon-modulating genes.
Twenty of the 506 toxicity-modulating genes have introns (table 2), corresponding to ~ 4%, indicating no significant enrichment for intron-containing genes among the toxicity-modulating genes.
Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal.
Some of the above niche-modulating genes can be considered therefore attractive therapeutic targets, especially SPP1 (or its product osteopontin) and IL8 because of their strongest induction.
Compared to the diploid hemizygous strains [ 65], the DAmP strains show a higher proportion of toxicity-modulating genes (data not shown).
