Here we describe an innovative method of modulating gene expression by making one animal that can express either low or high levels of a gene.
One route is to control cell behavior by modulating gene expression using conditional promoters.
It is one of few aptamers known to be capable of modulating gene expression in vivo.
miRNAs (microRNAs or miRs) are small RNA molecules modulating gene expression at the post-transcriptional level.
In neurons, the HAT/HDAC enzymes also target non-histone proteins, such as transcription factors and cytoskeletal proteins, thereby modulating gene expression and microtubule-based organelle transport9,10.
A new article published online in Nature Genetics reports that short tandem repeats, a class of genetic alterations in which short motifs of nucleotide base pairs occur multiple times in a row, play a role in modulating gene expression.
The National Institutes of Health have awarded eight grants as part of a new phase of the Genotype-Tissue Expression (GTEx) project to study the role that genomic variation plays in modulating gene expression and, ultimately, human disease.
By generating activating and inactivating germline and inducible alleles, and modulating gene expression using lentiviral vectors, these models allow us to characterize the function of candidate genes and pathways during tumor progression and metastasis in vivo.
In this study, the effect of modulating gene expression more broadly by overexpression of sigma factor genes on carotenoid production by C. glutamicum was characterized.
Sustained gene delivery could be particularly necessary in modulating gene expression in healing intrasynovial tendons and may be a promising approach for preventing adhesions.
There is increasing evidence that sequences other than upstream noncoding can contribute to modulating gene expression, but how frequently they do so remains unclear.
