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Protein phosphorylation and dephosphorylation are the most important regulatory mechanisms modulating functions of more than one third of the total cellular proteins [1].
Although the increased expression of miR-146a in T cells does not show any affect on cytokine production in this study, available data on overexpression of miR-146a in several types of cells of RA suggests that miR-146a is possibly involved in modulating functions of T cells and other cells in RA pathogenesis.
Interestingly though, knockout of muscarinic receptors of the cholinergic system, which plays an important role in modulating functions of the dopaminergic systems in the brain, did have an effect on both the structure and the usage of vocalizations: M2 and M5 KO mice produced fewer, and disproportionally fewer frequency modulated calls, whereas knockout of M4 had no effect.
Cholinergic systems play important roles in modulating functions of dopaminergic systems in the brain [20], [21].
In addition to stimulating tumour cell proliferation, EGF signalling has also been implicated in modulating functions of stromal cells in the tumour microenvironment, such as tumour-associated angiogenesis and bone metastasis (De Luca et al, 2008).
These results suggest that Ang II regulates the growth of pancreatic carcinoma cells through modulating functions of host stromal cells; Moreover, Ang II AT2 receptor signaling is a negative regulator in the growth of pancreatic carcinoma cells.
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Moreover, the tightly regulated cell type specificity of miR expression makes these molecules amenable to modulating function of individual cell types.
He is co-developer of nanoparticulate formulations of thyroid hormone analogues, such as tetraiodothyroacetic acid, that act exclusively at the hormone receptor on the integrin to modulate functions of the integrin.
The PI3K/Akt pathway can modulate functions of ABC transporters through various mechanisms.
In the same time, some AS events possibly modulated functions of proteins with multiple domains.
These examples showed that some AS events can modulate functions of proteins especially for ones with multiple domains.
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