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Our findings make the clear prediction that senescence and modulating factors such as oxidative stress are more (or only) important to the fitness of long-lived mammals.
LPL, described as a PPARα target gene restricted to Kupffer cells [37] was also always overexpressed, as well as its modulating factors such as APOC3 and ANGPTL4.
Most likely, nonmodifiable donor and recipient determinants synergize with potentially modulating factors such as immunosuppression 17.
This explains the basic sensitivity of IL-6 towards classical transcription modulating factors such as prostaglandins, cytokines, steroid hormones etc.
Furthermore, several time modulating factors, such as personality, attention and emotions have been described in the literature [ 2].
Furthermore, this trans-differentiation process is known to be tightly controlled by modulating factors, such as TGF-β1, BMP-7 and Hh signaling.
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By the age of 2 years, the bacterial population of the gut is established and remains relatively constant throughout life, though disease processes, surgical interventions, medical therapies, and epigenetic-modulating factors such as the diet can influence the gut microbiome.
In addition, a marked increase in cell growth-modulating factors (such as HGF, FGFβ, HB-EGF, and KGF) in the circulation of severe sepsis patients was also found.
Cancer cells actively influence their adjacent stroma by producing stroma-modulating growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), interleukins, and tumor growth factor beta (TGFbeta) [ 1, 2].
Although such modulating factors play an important role in task performance, they are rather general factors of cognitive efficiency that cannot facilitate regionally specific brain processes.
However, such modulating factors of cognitive efficiency are unspecific, can be difficult to control, and are not suitable to facilitate neural processing in a regionally specific manner.
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modulating processes such
modulating factors associated
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