(C ) dnc-EGFP-dnc can be spatially and temporally knocked-down and re-expressed with temperature shifts modulating expression of UAS-deGradFP under the control of the MB-GAL4 driver, 117y-GAL4.
In Arabidopsis thaliana, the miR156-SPL module regulates the formation of (E -β-caryophyllene in thE -β-caryophyllenethrough modulating E -β-caryophyllenesesquinerpene synthese gene TPS21.
In 5 of the 76 diseases, our goal was the over-expression of a paralog; the concept of treating a genetic disease by modulating expression of a gene that functionally compensates (at least partly) the mutation gene is a well-known but comparatively unused therapeutic approach exemplified by SMN2 induction in spinal muscular atrophy (7).
In addition, C. cellulovorans optimizes carbohydrase production by modulating expression of metabolism-associated genes encoding cellulosomal and non-cellulosomal enzymes, depending on the availability of polysaccharides (Matsui et al. 2013; Aburaya et al. 2015; Esaka et al. 2015).
Furthermore, ECT2 knockdown inhibited cellular proliferation in vitro by arresting cell cycle progression at the G1 phase by modulating expression of cell cycle-related molecules, which ultimately leads to inhibition of cyclin D1-CDK complex activity.
It has been shown that IFN-β may also exert its effect on Th17 cells through modulating expression of IL-1β, IL-23 and IL-27 in both humans and mice [23], [41]-[42].
Here, we presented data to show that pRB1 could also suppress E2F-1's transactivity on TSP1 promoter in a dose-dependent manner, which is consistent with the role of pRB1 in modulating expression of E2F-1 targets, further confirming that TSP1 serves as a bona fide target of E2F-1.
This would suggest that TGFβ1 might also be repressing translation/export of proteins or could be modulating expression of tissue-specific microRNAs (miRNAs), short nucleotide sequences involved in post-transcriptional gene regulation that have been implicated in endometrial function [29], [30].
In addition, we verified that Rxra mRNA level was not altered, ruling out the possibility that TCDD acted through modulating expression of the RAR partner.
The ERFs are secondary ethylene activated factors, which increase plant tolerance to stress by modulating expression of downstream stress-responsive genes [ 65].
