Sentence examples for modulating element in from inspiring English sources

Although not all of the relevant elements of rapamycin-sensitive signal transduction pathways have been elucidated, PI3K/Akt appears to be the key modulating element in the upstream pathway by which interactions between growth factors and growth factor receptors affect the phosphorylation state of mTOR.

In our previous genomic analysis, cobW genes were identified in Proteobacteria located within the cobalamin biosynthesis gene clusters under control of the B12 riboswitch, a regulatory RNA element modulating gene expression in response to changing B12 concentrations [ 49].

Importantly, it is also a decisive element in modulating different molecular pathways, such as the nuclear factor NF-κB pathway through recruitment of different signalling molecules and the extrinsic cell death pathway by promoting aggregation of caspase 8 (Ref. 108).

The marked increase of TFE3 after nephron reduction in both mice and humans suggests that the ratio between MITF-A and TFE3 rather than the absolute level of MITF-A protein is the key element in modulating TGF-α expression during CKD progression.

Therefore, this cytokine plays a crucial role in breast cancer progression by modulating key elements of ECM homeostasis control.

This result also suggests the implications of elements found in regulating human splicing and may help explaining human hereditary disorders caused by mutations modulating such elements.

Subtle changes (e.g., point mutation s) in the intronic sequences may enable pseudo exons splicing competent through modulating these elements.

To gain further insight into this mechanism, we searched here for elements that could be relevant in modulating Sdh1p expression, in response to alteration in flavin cofactor homeostasis.

In conclusion, NaO exerts a dual effect on S. aureus internalization in bMEC and modulates elements of innate immune response.

Rasgrf1 is an imprinted gene with monoallelic expression of the paternal allele modulated through methylation of a regulatory element in the parental allele, which blocks binding of the CTCF transcriptional repressor (reviewed in ref. 36).

Physical interactions between cis-regulatory elements and gene promoters can be identified by chromatin conformation capture methods, which provide mechanistic evidence to support hypotheses regarding the role of distal regulatory elements in modulating expression of particular genes and how this may be modulated by specific regulatory genetic variants.