Indeed, achieving control of percentage active in a population without introducing heterogeneity requires modulating duration of a high-dose input.
However, modulating duration of the SS signal from 1 s to 40 s (activating 3.3% and 87.5% the population, respectively) changes median response timing by less than 2 min. Statistical analysis indicates no significant difference in response time under varied pulse durations.
Subsequently, MCC-IE(k) peptide contacts dominate stabilization, imparting specificity and influencing T-cell activation by modulating the duration of binding.
Activation of gene expression in human cells engineered with LITEZ was reversible and repeatable by modulating the duration of illumination.
Although both elephants employed the strategy, one was clearly better at it, modulating the duration of her blows to bring objects where she wanted them, the researchers reported 5 November in Animal Cognition.
Finally, the combination of this experimental approach and simulations using single cells uncovers a new role for the M-current in modulating the duration of bursts of hyper-excitable activity.
Although BK stimulates the release of nitric oxide from the vascular endothelium, the released nitric oxide and its ability to stimulate guanylate cyclase only modulates the duration of, rather than the magnitude of, BK-induced coronary vasodilation.
The data support the conclusions that the coronary vasodilator response of the rat to BK is CYP-1A and KCa-channel mediated, that coreleased nitric oxide only modulates the duration of BK-induced vasodilation, and that these mechanisms are unaffected by moderate diabetes.
Local drug metabolism, the action of transporters, the rate of absorption, and receptor binding, modulate the duration of local action.
Proteins of the regulators of G protein signaling (RGS) family modulate the duration of intracellular signaling by stimulating the GTPase activity of G protein alpha subunits.
We observe that acquisition of clinical immunity modulates the duration of infections, which in turn is responsible for the identification of transmission regimes where stable endemic equilibria coexist with stable disease-free solutions.
