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Satellites are capable of modulating disease expression, however (19).
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However, we anticipate that other CFTR mutations in addition to CFTR-ΔF508 as well as other diseases entirely can be analogously modeled in yeast to generate useful insight and new hypotheses as to how networks of interacting genes might modulate disease expression.
IL-10 is both an immunoinhibitory (monocytes and T cells) and an immunostimulatory (B cells) cytokine that may confer susceptibility and modulate disease expression in rheumatoid arthritis (RA).
Sex chromosome-dependent gene expression variation in immune response genes might be one pathway for modulating disease phenotypes.
This implies that the motifs discovered here are strong candidates for modulating disease-related changes in gene expression.
It is feasible that the length of the treatment period (10 weeks) is too short to modulate clinical disease expression under the cover of concurrent treatment.
Evidence further suggests that TMEM106B risk genotypes/increased TMEM106B expression may modulate disease risk by affecting progranulin pathways.
We identified several microRNAs that may be involved in emphysema pathogenesis and appear to modulate disease-specific gene expression networks.
LncRNAs regulate gene expression, thus having the possibility to modulate disease progression.
These lesions also showed mosaic expression of SNF5 by immunohistochemistry. Therefore, our studies implicate that modest changes in angiogenic regulation interact with perturbations of SWI/SNF complex activity to modulate disease phenotypes.
It was proposed that a functional variant rs2488457 in PTPN22 increases susceptibility to VKH disease via modulating the expression of PTPN22, production of interleukin 10 (IL-10) and proliferation of peripheral blood mononuclear cells [[107]].
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