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Thus, the identity of polymorphic genes modulating development of allergic sensitization may vary depending on specific environmental exposures.
Interestingly, the latter lesion was selectively induced in males and not in females, which confirms the results of a previous study 27 and is consistent with the recognized influence of sex hormones in modulating development of bladder cancer 28.
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These data also support therapeutic efforts that seek to modify gut microbiota as a means to modulate development of this disorder.
Interestingly, within this context, our results described here would instead suggest that these NMDA receptors might modulate development of BG in the cerebellum.
Previous investigators [ 2- 4] have suggested at least three factors could modulate development of monozygotic multiple gestations in the setting of the advanced reproductive technologies: ovulation induction per se, certain IVF culture conditions, and zona pellucida architecture/micromanipulation.
Caloric restriction (CR) has been shown to extend lifespan in many species and has been extensively used in experimental gerontology to modulate development of age-related diseases (Weindruch and Sohal, 1997).
ER-β, on the other hand, modulates development of extracellular matrix, leading to normal elastic tissue recoil pressure in the lungs [ 30, 31].
The nature of the microbiota, as discussed earlier, modulates development of the brain and HPA axis 7– 9 and the microbiota plays a major role in the inflammatory response to stress 9.
Together, these data suggest that a combination of TCR affinity and signals derived from Itk regulate Th-POK expression, thus modulating the development of CD4+ T cells.
Additional factors mediating or modulating the development of vascular calcification in patients with ESRD remain to be identified.
Others have shown that TF is upregulated in the lung in response to bleomycin-induced lung injury [22 25, 30] and that procoagulant pathways are important in modulating the development of pulmonary fibrosis following an acute insult.
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