However, ZD6474 does not modulate chemosensitivity in parental chemosensitive cells.
Our work provides a rationale for using elongation inhibitors to modulate chemosensitivity in tumors.
To address whether inhibitors of translation elongation could also synergize with DNA damaging agents (e.g. Dxr), we tested the potential of four elongation inhibitors to modulate chemosensitivity in the Eμ-myc model harboring lymphomas with loss of Pten or Tsc2 or over-expressing Bcl-2 or eIF4E.
In addition, a shortcoming of these assays is that they do not assess for a compounds' ability to modulate chemosensitivity.
eIF4E is oncogenic in vivo and in Eμ-Myc lymphomas over-expressing this factor, rapamycin is unable to modulate chemosensitivity whereas silvestrol can [6], [16], [18], [19].
Other in vitro studies have shown that increased miR-21 expression promoted invasion and metastasis and could modulate chemosensitivity (Asangani et al, 2008; Blower et al, 2008; Zhu et al, 2008).
Therefore, the effect of modulating the chemosensitivity of breast cancer cells to ADR was obtained.
In this model, activating lesions in PI3K/AKT/mTOR signalling not only accelerate tumorigenesis, but also modulate chemosensitivity [4], [5], [6].
On the basis of its ability to block IGF-IR and modulate chemosensitivity, the addition of figitumumab to docetaxel may improve the antitumour activity of single-agent docetaxel.
Our previous work and that of others have shown that changes in the expression level of specific β-tubulin isotypes can modulate the chemosensitivity of cancer cells not only to microtubule-targeting agents but also to other classes of chemotherapeutic drugs, such as DNA-damaging agents (reviewed in [ 33]).
