Several studies have emphasized the influence of environmental cues, antigen dose, and specificity of the APCs recruited to the T cell activation site in shaping the response by modulating cell function (reviewed in [27]).
Several studies have emphasized the influence of antigen dose, microenvironment, and specificity of the APCs recruited to the CD8+ T-cell activation site in shaping the response by modulating cell function [43].
Although our previous studies have suggested actomyosin interactions as effectors of modulating cell stiffness [11], these studies were performed using butanedione 2-monoxime, or BDM, which has since proven to lack the specificity and potency as a nonmuscle myosin inhibitor as was originally presumed [23].
ROS induces cell death by modulating cell signaling pathways.
JNK has an important role in modulating cell cycle progression.
Relative specificity, therefore, enables mTORC1 to differentially phosphorylate substrates under the same physiological inputs, which modulates cell behaviors and drug sensitivity.
It is known that nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell cell communication, and modulate cell structure [7, 8].
We modulate cell redox state in several experiments.
Thanks to its many membership sites, it modulates cell adhesion.
Targeting a molecular pathway that is upregulated in cancer cells may provide tumor specificity and help to overcome some of the potential issues with severe autoimmunity when modulating immune cell populations.
