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Genetic and biochemical studies have shown that Mycobacterium tuberculosis serine/threonine protein kinases PknA and PknB play a role in modulating cell shape and possibly cell division.
This change can affect the subsequent chondrogenesis of MSCs as it has been shown that collagen type II favors chondrogenic induction by modulating cell shape, as compared to collagen type I [ 95].
These results suggest that AFAP1L1 plays a role in the progression of CRCs by modulating cell shape and motility and by inhibiting anoikis, presumably through interactions with vinculin-including protein complexes.
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Based on the results obtained in DC we propose a model in which cells could control their shape by regulating the balance between endocytosis and recycling and we suggest this to be a mechanism widely used in morphogenesis to modulate cell shape changes (Figure 6H).
AFAP1L1 can modulate cell shape and motility, presumably partially through interactions with vinculin, and may play a role in the inhibition of anoikis.
The present in vitro studies are also important since they afford an experimental opportunity to modulate cell shape, ECM production and proliferative capabilities in a human cell type about which there is still relatively little in vitro information.
Invasive behavior is strongly influenced by stromally produced TGF-β signal, which is processed by the pSmad2L/C pathway to modulate cell shape, adhesion and localized proteolysis in the nearby extracellular matrix.
A microgravity environment may influence the oscillating behavior of the nucleus [ 22] and then trigger a series of mechanical adjustments that may modulate cell shape and structures, as well as functions by way of transcription activities.
Additionally, filamin-A acts an adaptor that mediates the complex connections between the integral membrane proteins and actin filaments, which enables filamin-A to modulate cell shape at specific areas.
While the focal adhesion-associated PINCH1 may play a critical role in modulating cell adhesion, cell shape and survival [33], we show here that nuclear PINCH1 is instrumental in regulating gene transcription via its interaction with WT1.
In S. pombe, complex molecular networks have been identified that modulate cell shape, and therefore may be involved at some level in regulating cell wall machinery.
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