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Bacterial infection can trigger apoptosis by modulating caspase expression.
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We also evaluated the impact of modulating caspase-14 expression on RPE cells barrier function, phagocytosis, and activation of other caspases using ARPE-19 cells transfected with caspase-14 plasmid or caspase-14 siRNA.
Since RPE barrier dysfunction includes changes in the TER across the confluent monolayer, we evaluated the effect of modulating caspase-14 expression on RPE TER under NG or HG condition.
The PAMPs that mimicked bacterial infections (LPS, CPGs and LTA) were able to modulate caspase gene expression.
The finding that rapamycin is unable to modulate caspase-2L expression is a first hint that HuR may affect IRES-mediated translatiof of caspase-2L.
In addition, NsTyr attenuated sevoflurane-induced apoptosis by modulating Caspase-3 and Bcl-2 in vivo.
Intriguingly, leptin was shown to enhance IL-18 secretion from human monocytes by modulating caspase-1 inflammasome function [31].
This indicates that ischemia-induced zinc accumulation plays a role in modulating caspase-independent neuronal death following transient cerebral ischemia.
It was shown that Pgp could modulate caspase activation, e.g., caspase 8, and inhibit apoptosis [ 60].
Thus, Src might directly modulate caspase-3 and -7 activities.
Anti-cancer drugs can also block the cell cycle and inhibit cell growth, while activating caspase cascades and modulating telomerase expression and activity [ 23– 25].
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