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The study conducted here is an attempt to explore NF-κB signalling pathway modulating capability of Withania somnifera's major constituent WA and to elucidate its possible mode of action using molecular docking and molecular dynamics simulations studies.
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Of note, this competence pertains solely to DMT1 since acid-sensing ion channels are reported not to be expressed in the plasma membrane of hippocampal astrocytes [58,59] while the activation of TRP vanilloid 1 (TRPV1) nocisensors [60] with capsaicin did not modulate the capability of astrocytes to uptake iron (not shown).
Motivation: Metabolic engineering aims at modulating the capabilities of metabolic networks by changing the activity of biochemical reactions.
Several other IgG engineering technologies have been reported that have the potential to modulate the capabilities of existing and future clinical candidates (Table 8).
We next examined whether HSP70 modulated the capabilities of apo-SAA to induce pro-inflammatory cytokine production.
A novel series of molecules were designed with multiple sex-steroid receptor modulating capabilities by coalescing the pharmacophores of known anti-CaP molecules that act via modulation of ER and/or AR, viz.
Whether the inhibitors are acting directly in the amastigotes or indirectly, modulating the killing capability of the macrophages, remains an open question.
Chemoradiation induces tumor antigen-specific T-cell responses in clinical settings, which have the capability of modulating the clinical outcome of malignant diseases.
Some polymer NPs were reported to activate immune system through modulating the activation and capability of immune cells, such as dendritic cells and T cells [ 114– 114].
Altering the structure of metabolic networks provides the means for modulating their capabilities.
Both, the association with binding partners and the observed tyrosine phosphorylation might negatively modulate the RNA binding capability of Sam68 [ 96].
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