Sentence examples for modulating autophagy in from inspiring English sources

These outcomes provide a better understanding of the role of Nrf2 in modulating autophagy in an AD mouse model and may help design better Nrf2 targeted therapeutics that could be efficacious in the treatment of AD.

Different signaling pathways may be involved in modulating autophagy in ECs.

In vitro LC3 lipidation requires energy and is subject to regulation by the pathways modulating autophagy in vivo.

Clinical trials to evaluate the therapeutic effect of modulating autophagy in combination with chemotherapy are underway in patients with prostate, breast, and lung cancer (White and DiPaola, 2009).

Since Tu212 cells responded to RRM2 siRNA treatment in vivo and induction of autophagy marker was observed following silencing of RRM2 in cell culture (Fig. 2A), we further evaluated the role of dNTP levels in modulating autophagy in Tu212 in vivo.

However, pharmacological inhibition of eEF2K with or without CQ did not have a discernable effect on the LC3-II/LC3-I ratio under non-starving conditions (Fig 7E), suggesting that eEF2K does not sustain growth by modulating autophagy in Pten/p53-deficient tumor cells.

We list MTOR as a negative modulator because it negatively modulates autophagy in the presence of sufficient nutrients.

Therefore, we hypothesized that PHGDH may modulate autophagy in ECSLCs.

We show that raw-DWCNTs could also modulate autophagy in tumor cells through induction of intracellular acidification.

To understand the mechanism by which PHGDH modulates autophagy in ECSLCs, we probed the mTOR signaling pathway, as phosphorylated mTOR (p-mTOR) is a major negative regulator of autophagy following various stress-inducing stimuli, such as energy and nutrient deprivation38.

Hence geldanamycin derivatives may provide a means to modulate autophagy in neural cells, thereby ameliorating pathogenic aggregate formation and protecting the cells during disease and aging.