To test whether angiotensin II (AngII) could modulate apoptosis of human granulosa-lutein (GL) cells from gonadotropin-stimulated follicles.
These observations indicate that two candidate genes for T1D may act, at least in part, at the β-cell level, modulating apoptosis and the generation of inflammatory signals in the course of a viral infection.
Therefore, any attempt of modulating apoptosis with this approach was inconclusive.
Some reports suggest that Bcl-xL, but not Bcl-2, is capable of modulating apoptosis induced by tumor necrosis factor-related apoptosis ligand (TRAIL) [ 25].
Given the role of sFRP2 in modulating apoptosis and glucose metabolism, future experiments evaluating the effect of sFRP2 on mitochondrial OXPHOS in the WT-and MRL-MSCs are notable future endeavours.
These include actin bundling, nuclear export of aa-tRNAs, proteolysis of misfolded proteins, modulating apoptosis, response to amino acid starvation and viral replication [ 9, 10].
In addition to modulating apoptosis, EPO maintains the integrity of capillary function (e.g. the blood brain barrier [ 38]).
As several of the genes shown in Figure 2 are important in regulating proliferation and survival, and because of the recently described role of MUC1 in modulating apoptosis in response to cellular stresses [ 20, 21, 24], we first analyzed whether MUC1 siRNA would alter apoptosis in these lines.
Furthermore, experimental studies with macrophages demonstrated an involvement of NR4A1 in modulating apoptosis in the inflammatory response.
For example, experiments performed with heavy ions or cytochrome C as inducers of apoptosis demonstrated cell death in untreated neighbouring cells, which points towards a role of GJs in modulating apoptosis.
