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This review discusses the application of engineered materials for the delivery of immune modulating agents to the tumor microenvironment, therapeutic cancer vaccination, and adoptive T cell therapy.
Several modulating agents to prevent nephrotoxicity, such as thiosulphate (Leeuwenkamp et al, 1991), diethyldithiocarbamate (Gandara et al, 1995; Paredes et al, 1988), glutathione (Smyth et al, 1997), amifostine (Kemp et al, 1996; Hartmann et al, 2000) and mesna (Leeuwenkamp et al, 1991; Hausheer et al, 1998; Boven et al, 2002), have been investigated.
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The importance of responsiveness to modulating agents for the function of BvgS in vivo, and the relevance of nicotinate and MgSO4 are unclear.
Considering the better understanding of the participation of host immune-inflammatory mediators in disease progression, the use of modulating agents as an adjunctive therapy to the periodontal treatment has been encouraged to provide innovative visions of the management of periodontitis [ 5, 21, 22, 37, 38].
These findings demonstrate the utility of BAR to noninvasively monitor AKT activity in preclinical studies in response to AKT modulating agents.
Modulating agents (antiproteinase, anti-inflammatory) seem to be of interest in gingivitis and periodontitis.
Ion-channel modulating agents are a potential tool to further investigate aspects of the cyanobacterial stress response and related metabolisms.
Delivering a higher radiotherapy dose to areas of the tumour that are less likely to respond, or integrating physiological modulating agents into the CRT regimen, may increase the likelihood of pCR without increasing treatment toxicity.
MKP-1 modulating agents such as rosiglitazone and triptolide were used to demonstrate MKP-1's role in tumorigenesis.
The chicken embryo chorioallantoic membrane (CAM) is widely used as an in vivo model to study the vascular effects of angiogenesis modulating agents.
In addition, varying light intensity or photoperiod could result in substantial changes in the cyanobacterial physiological response to pH, Na+ stress or ion-channel modulating agents.
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