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This role is accomplished by regulation of the expression of transmembrane P carriers and by modulating activity of the hydroxylases that activate or catabolize vitamin D. All of these FGF23 effects are obtained through activation of specific receptors.
More importantly, we found that FANCD2 is capable of modulating activity of DNA translesion synthesis polymerase eta, an effector of HHR6 pathway.
Our recent study indicates that IQGAP1 is capable of modulating activity of b-Raf [27], to test whether IQGAP1 activity is also required for b-Raf phosphorylation in endothelial cells in response to VEGFR-2 activation we tested phosphorylation of b-Raf where expression of IQGAP1 is knocked down by siRNA.
So the inhibition of DAPI efflux supports the hypothesis of antibiotics modulating activity of thymoquinone through pump efflux inhibition.
We confirmed the cell death modulating activity of the chemicals and genetic materials in our previous report.
Additionally, cigarette smoke may affect the pharmacokinetics of inhaled drugs by modulating activity of specific drug metabolizing enzymes (Durak et al. 1996).
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Therefore, OsCYP2 may be a key regulator that controls ROS level by modulating activities of antioxidant enzymes at translation level.
smt3 protein may modulate activity of transcription factors in the follicle cells downstream of EGFR activation.
However, WT- and PTX3−/−-MSCs did not seem to modulate activity of MMP13 in 1 week (Additional file 1: Figure S2) to impact remodeling and fibrosis.
Like the homologous FOG-1-GATA-1 pairing, Ush modulates activity of the Drosophila GATA factor Srp [39] to favour plasmatocyte differentiation [22].
LPS can modulate activity of cPLA2 by phosphorylation [ 20].
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