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The enzymatic activation of eNOS is achieved by modulating activities of PP2A and AMPK, resulting in specific changes in eNOS phosphorylation at Ser and Thr.
Taken together, this study illuminates the signal modulating activities of FMOD beyond its structural support functions, and highlights the potential for FMOD-based therapies to be used in cutaneous wound repair.
Here, we report that hypoxia-induced miR-215 is vital for reprograming GICs to fit the hypoxic microenvironment via suppressing the expression of an epigenetic regulator KDM1B and modulating activities of multiple pathways.
Therefore, OsCYP2 may be a key regulator that controls ROS level by modulating activities of antioxidant enzymes at translation level.
Together, these data suggest that OsCYP2 may act as a key regulator that controls ROS level by modulating activities of antioxidant enzymes at translation level.
Our data suggest a correlation between S100A expression and sensitivity for Calphostin C. Mechanistically, Calphostin C may enhance apoptosis either via elevation of intracellular calcium levels or via inhibition of PKC, modulating activities of bHLH proteins [ 46, 69, 71].
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More importantly, we found that FANCD2 is capable of modulating activity of DNA translesion synthesis polymerase eta, an effector of HHR6 pathway.
So the inhibition of DAPI efflux supports the hypothesis of antibiotics modulating activity of thymoquinone through pump efflux inhibition.
We confirmed the cell death modulating activity of the chemicals and genetic materials in our previous report.
Genistein has been shown to modulate activities of PTKs [25], [26], [27].
In the kidney, HNF-1β, a transcriptional factor, has been shown to modulate activities of several target genes in tubular epithelia, namely Umod, Pkhd1, Pkd2 and Tg737/Polaris.
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