Lesions in parts of the cerebellum are hypothesized to modulate actions via a "dysmetria of thought" [ 9].
This means that in terms of function, APP processing via the β-pathway has the potential to either: modulate actions of sAPPα via competition with sAPPβ; or modulate the actions of sAPPα and initiate actions mediated by Aβ.
We have previously reported similar HLA1-modulating actions of some chemotherapies (Liu et al, 2010), and so adopted similar models to investigate the effect that the exhausted media from PBMCs cultured with BCG could have on HLA1 expression in a panel of tumour cell lines.
Furthermore, heparin may be capable of modulating the extent of remodelling of the airway wall seen in asthma by modulating the actions of a range of proteins including ECM proteins, growth factors and certain enzymes, and by inhibiting the proliferation of lung fibroblasts and airway smooth muscle cells [ 58].
This change in the F1P pool could have global metabolic effects through modulating the actions of the catabolite repressor/activator protein Cra (also known as FruR).
Although other reports have pointed to individual pathways modulating the actions of some OPN splice variants in different tumor models [ 5], none of them has investigated putative interacting signaling networks and their relationships to functional data.
Because the window for PTH stimulation of OB differentiation in Cox-2 KO cultures was early in culture and because PGs cause PTH to decrease both OB and adipocyte differentiation, it is possible that PGs are modulating the actions of PTH on MSCs, which are likely to be available only early in culture.
However, this residue is not conserved among suramin sensitive receptors, and it has been suggested that it is the localized positive charge that is important in modulating the actions of the negatively charged suramin (Braun et al., 2001; Sim et al., 2008).
Exosomes play an important role in intercellular communication and have been described to regulate immune functions, tumor migration and modulate the actions of drugs[32].
Epidermal growth factor (EGF) modulates the actions of gonadotropins in the corpus luteum.
