Sentence examples for modulating DCs in from inspiring English sources

The development of biomaterials capable of modulating DCs in situ to enhance antigen uptake and presentation has emerged as a novel method toward developing more efficient cancer vaccines.

DCs are critical in immunoregulation, and are known to express high levels of C-type lectin receptors, such as mannose receptor, suggesting a potential utility for the design of strategies targeting and modulating DCs.

We then took a further insight into the role of PRL in modulating DC and Treg phenotypes in the mouse intestine.

Significantly, although both pathways activate STAT3, they modulate DCs maturation in a different manner that results in disparate phenotypic outcomes.

Further research has demonstrated that glycans present in T. crassiceps excreted/secreted (TcES) molecules are also important in modulating DC maturation [ 64].

However, these studies agree that this compound exerts its immunological action, at least in part, by modulating DC properties.

In the future, it will be important to explore and exploit the benefit of ligand treatment to modulate DC immunogenicity in vivo.

Indeed, neutrophils can modulate DC maturation and, in turn, the proliferation and polarization of T cells [ 7].

During recent years, studies have been undertaken in an attempt to modulate DC functions or to reprogramme Th differentiation [ 111– 111].

Although TGFβ is known to modulate DC maturity, 18 our studies implicate disruption of TGFβ signalling in DCs as a critical event in the development of autoimmunity.

Co-culture of epithelial cells together with DC has been reported to modulate DC function [54], [55] indicating that these cells may account for the residual activity of PP-DC isolated from GF mice in the promotion of IgA production.