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We also demonstrate that the single-nucleotide polymorphism (SNP) that is located immediately adjacent (3′) to the repeats of the SCA3 transcript modulates the structures formed by these sequences, and may have functional significance, as only one of its variants is selected in human evolution.
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This demonstrates that biochemical engineering not only modulates the structure of cell surface sialic acids, but that biochemical engineering also influences biological stability of defined glycoproteins.
Although we currently do not know the mechanism by which AGS3 modulates the structure or function of the late Golgi compartments, the observations that USP9x interacts with AGS3 and regulates the level of AGS3 are consistent with a role of ubiquitination/deubiquitination of AGS3 in this process.
The crystallographic analysis demonstrated that the formation of AA-NAT/14-3-3 AA-NAT/14-3-3 AA-NAT/14-3-3 AA-NAT/14-3-3f substrate binding sites, enabling the increase in the affinity for arylalkylamines [ 31].
Feng et al. showed that stereochemistry at the α carbon modulates the structure of α- N-dA adducts 2 of styrene oxide.
In vitro, KSRP also modulates the structure of the let-7 TL, freezing it in one of two possible conformations (G. Nicastro, D. Hollingworth and A. Ramos, unpublished work).
- Understanding the mechanisms through which PTEN modulates the structure, function, and plasticity of cortical networks is a major focus of study.
In the future, it will be interesting to analyze molecular interactions in a putative tripartite STAT-H1-HP1 complex in the context of chromatin and to examine how STAT92E modulates the structure of the chromatin fiber in vitro.
In monomeric polypeptides, the oligoPro flanking segment adopts a PPII conformation that modulates the structure of multiple preceding Gln residues, presumably allowed in part by Gln's innate propensity for PPII structure.
During synaptic plasticity, neurotransmitter released from the pre-synapse is thought to signal changes in protein production at the post-synapse, which modulates the structure and efficacy of the post-synapse.
This construct placed two positively charged amines adjacent to the major groove edges of two symmetry-related guanines, providing a model for probing how cation binding in the major groove modulates the structure and stability of DNA.
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