Sentence examples for modulates the phenotype from inspiring English sources

We demonstrate that p53 modulates the phenotype of specific cell-cycle defects through distinct mechanisms, depending on the defect.

Because Tregs can be induced locally by DCs with an immature phenotype that produce IL-10 [29], [30], [30], it is possible that TBHsp70 modulates the phenotype of DCs, inducing a regulatory response, and IL-10 production by DCs, leading to the recruitment and/or induction of Tregs.

Regardless of the experimental technology used, the screening strategies aim to quantify the extent to which a mutation in one gene modulates the phenotype (or fitness) associated with altering the second gene, either by explicitly measuring or analytically comparing the observed fitness of double-mutants to those of single-mutants.

Our data show that myelin modulates the phenotype of macrophages by PPAR activation, which may subsequently dampen MS lesion progression.

It is becoming more and more evident that the ECM genotype modulates the phenotype of cells [ 33] and by that the cellular response to different stimuli.

This observation strongly suggests that understanding how the extracellular matrix modulates the phenotype of bladder cancer cells is highly relevant to understanding the processes of recurrence and progression.

The purpose of this work was to investigate if a coculture system of human mesenchymal stem cells (hMSC) with endothelial cells (human umbilical vein endothelial cells, HUVEC) could modulate the phenotype and proliferation of harvested MSCs.

A high negative correlation predicts that the agents could modulate the phenotype, but do not indicate their potency in doing so.

Instead, we speculate that changes in mitochondrial Zn pools may perform regulatory functions to modulate the phenotype of the highly differentiated secretory epithelium during lactation.

On the other hand, it did not segregate with the clinical phenotype because it occurred in two patients with different clinical findings and its association with rRNA deletion (in P3) or tRNA variant (in P9) might be modulating the phenotype of these two patients.

This observation highlights the importance of genetics and environmental variations in modulating the phenotype in humans.