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However, findings obtained from ReA patients suggest that HLA-B27 modulates the interplay between ReA-triggering bacteria and immune cells, leading to abnormal host microbe interaction.
It is tempting to speculate that the activation of EphB forward signaling by Reelin shown here modulates the interplay between amyloid-β, Reelin and EphB signaling in the regulation of NMDA receptor-dependent functions at the synapse.
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Co-chaperones that modulate the interplay of Hsc70 and Hsp70 with the ubiquitin-proteasome system (UPS) and the autophagosome-lysosome pathway emerged as key regulators of this process.
The present findings provide this evidence by showing for the first time that individual differences in trait anxiety modulate the interplay between emotion-sensitive and executive control brain regions.
These observations suggest that c-kit signalling together with gp130 signalling are potent regulators of hematopoietic stem/progenitor cells including those of human origin, and we have shown that Lhx2 expression efficiently modulate the interplay between these receptors.
There is growing awareness that drivers of disease emergence modulate the interplay between pathogens, hosts and environment.
Human actions that modulate the interplay between pathogens, hosts and environment are at the basis of almost all EID events, although the exact drivers and mechanisms differ.
At the very outset of the discussion, it needs to be realized that the excitation rate is modulated by the interplay between several factors of different characteristics.
The latter is known to be a highly variable and complex phenomenon modulated by the interplay of several factors, none of them with predominant influence, many of them under genetic control [27].
Under normal conditions concentrations of calcium are highly modulated by the interplay between parat hormone (PTH), calcitonin and vitamin D. In hypocalcaemic conditions parat hormone and 25-OH-Vitamin D3 are upregulated.
The balance between cytostatic vs cytotoxic effects induced by CDDP in cancer cells is a consequence of DNA damage produced by CDDP-DNA adducts, which is in turn modulated by the interplay between tumour suppressors and oncogenic signalling controlling DNA synthesis, suppression of RNA transcription and effects on cell cycle, cell survival and death (Wang and Lippard, 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com