Sentence examples for modulates the downstream from inspiring English sources
Apparently RA simultaneously activates expression of both HoxB1a and miR-10 and miR-10 modulates the downstream response to retinoid signaling.
PLCγ1 phosphorylation modulates the downstream signal transduction of a variety of growth factors, including PDGF [ 9].
Upon G6PD knockdown, such NADPH sensor modulates the downstream signaling required for normal hatching.
In addition, we determined that SHP2 activity is required for the downregulation of phosphorylated ERK1/2, which modulates the downstream effectors, Snail and Twist1 at a transcript level.
IRRP3 (123–140) modulates the downstream signaling pathways, so that amino acid changes in this region can explain some differences in biological activity among different IFNA.
Low P availability alters the local concentration, transport or sensitivity of intracellular compounds such as carbohydrates, especially sugars, auxins, ethylene, cytokinins, NO and ROS, and subsequently modulates the downstream genetic elements that control the initiation and maintenance of root development.
The major readout of the Hippo-YAP/TAZ pathway is modulating the downstream target gene transcription via interacting with and coactivating TEADs transcription factors (Zhang et al., 2009).
The N and C terminals may allow PRG4 to simultaneously interact with multiple receptor families and modulate the downstream signaling of its binding partners.
Several polyunsaturated fatty acid species have been shown to differentially modulate the downstream expression of FXR targets, enhancing and inhibiting agonist-induced BSEP and kininogen expression, respectively.
In the B16-F10 melanoma cell line MIF was induced by hypoxia and in turn modulated the downstream response to hypoxia, as exemplified by the reduction in VEGF expression level elicited by MIF shRNA.
Thus, blocking certain interactions that mediate the formation or stabilization of oligomeric toxic entities, or modulating the downstream effects of such interactions, could be an attractive treatment option for this class of diseases.
