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In recent years, alternative splicing emerges as an important molecular mechanism that modulates the clock function in plants.
As SIRT1 has been linked to life span and suggested to mediate CR-induced effects [ 115, 126, 253], it could be a candidate that modulates the clock of calorically restricted animals, as discussed above.
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As our work indicates that shits1's effects operate by compromising endocytic pathways, we suggest that membrane events leading to PKA signaling may modulate the clock by regulating expression, turnover, and/or activity of CLK.
In addition, growth hormones and abiotic stresses modulate the clock function.
However, a deeper understanding of the underlying molecular mechanisms that modulate the clock, and give rise to organ-specific clock transcriptomes, will be required to fully realize the power of chronotherapies.
Although we have clearly delineated a role for USP2 in modulating the ubiquitination level of PER1, this does not exclude the possibility that USP2 is involved in modulating the clock through additional mechanisms.
2) Alternatively, the shortening and lengthening period effects of the CCA1 and RVE8 subsets are compensated and you might conclude that these Mybs simply modulate the clock, presumably linking it to the light input.
These receptor ligands act on the endogenous receptors in an autocrine and paracrine manner and exert more sustained stimulation than nerve impulses to the receptors and hence modulate the clock activity.
Hardman, J. A., Haslam, I. S., Farjo, N., Farjo, B. & Paus, R. Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle.
ABA modulates expression of the clock genes through the induction of TOC1 expression followed by suppression of TOC1 target genes.
This is a nice example of how a peripheral metabolic regulator can modulate the central clock in the SCN.
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