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Our data strongly argue that CLCA4 modulates the capability to express residual chloride secretion in colonic tissue.
These findings suggest that CLCA4 modulates the capability to express residual chloride secretion in colonic tissue and therefore acts as a modifier of the basic defect in intestinal cells of CF patients.
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Of note, this competence pertains solely to DMT1 since acid-sensing ion channels are reported not to be expressed in the plasma membrane of hippocampal astrocytes [58,59] while the activation of TRP vanilloid 1 (TRPV1) nocisensors [60] with capsaicin did not modulate the capability of astrocytes to uptake iron (not shown).
Several other IgG engineering technologies have been reported that have the potential to modulate the capabilities of existing and future clinical candidates (Table 8).
We next examined whether HSP70 modulated the capabilities of apo-SAA to induce pro-inflammatory cytokine production.
Motivation: Metabolic engineering aims at modulating the capabilities of metabolic networks by changing the activity of biochemical reactions.
Whether the inhibitors are acting directly in the amastigotes or indirectly, modulating the killing capability of the macrophages, remains an open question.
The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (PD-1), CD244 and lymphocyte activation gene-3 (LAG-3), which modulate the functional capabilities of CD8+ T cells.
This factor has bacteriostatic, bactericidal and some immune modulating properties, but also the capability to bind LPS (reviewed in [ 37]).
The appearance of these HeLa-AS spheroids suggested that the effect of AS, which leads to reduced capacity of the FL CA IX to modulate pH could influence the capability of cells to survive these microenvironmental stresses.
Therefore, the polymer dielectric surface holds the capability to modulate the electronic properties of the devices [14, 15], and many methods have been applied to modify the surface [16 18].
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