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Bobbs, A. S., Saarela, A. V., Yatskievych, T. A. & Antin, P. B. Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning.
Chromatin immunoprecipitation (ChIP) indicates that Cobra1 binds to the Lef1 promoter and modulates the abundance of promoter-bound RNA polymerase.
Our study has shown that the COM1p modulates the abundance of oxidoreductases, thereby also affects the energy turnover from alternative pathways.
Thus, NMD eliminates or modulates the abundance of aberrant mRNAs, which balances and regulates different isoforms within the total mRNA reservoir (Nicholson et al, 2010; Huang & Wilkinson, 2012).
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For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs.
In soft-bottom tidal flats, sediment stability is one of the crucial parameters modulating the abundance and composition of benthic assemblages.
We have developed a strategy for dynamically modulating the abundance of native enzymes within the host cell and applied this to a model system for myo-inositol production from glucose.
Using a weight loss program, Ley and colleagues [7] demonstrated that a decrease in the F/B ratio in obese individuals correlated with weight loss over time and suggested that modulating the abundance of specific bacterial communities might be beneficial in the treatment of obesity.
In contrast, most macromolecular therapies focus on targeting a single receptor or modulating the abundance of a single gene product.
Deletion of the COM1 also modulated the abundance of two hydrolases, viz., PP2Ac and a lipase domain containing protein.
In contrast, many therapeutic approaches focus on modulating the abundance of a single gene product or targeting a single receptor.
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