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The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.
Therefore, we subsequently investigated whether cafestol modulates stability of Mcl-1 protein.
Moreover, we tested whether TNFα, a classical activator of NF-κB signaling, modulates stability of RARα protein.
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The ability of PINK1 to mediate turnover of mitochondrial proteins is not unusual given its role in modulating stability of membrane-bound respiratory chain subunits (Vincow et al., 2013).
We use molecular dynamics simulation to find the most cleavage-prone arrangement of α chains in a collagen triple helix and find amino acids that modulate stability of the MMP cleavage domain depending on the chain registry within the molecule.
Very recently, USP17 has been identified to be highly expressed in primary lung, colon, esophagus, and cervical cancers and also modulates the stability of p27Kip1 in G1 [25].
Indeed, in cells transfected with USP19 siRNA p27Kip1 levels remained relatively stable over time whereas the half-life of the protein was significantly lower in controls (Fig. 3D), implying that USP19 modulates the stability of p27Kip1.
Each 3'UTR modulates the stability of the mRNA transcript and can respectively decrease (c-Fos) or increase (bGH) steady state levels of mRNA in both cells and whole animals [24] [27].
It modulates the stability of HIF-1a mRNA, thereby impacting on the regulation of angiogenesis.
We next determined whether acetylation modulates the stability of RASSF5 in transformed cell lines.
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