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In this case, translation of the uORF modulates repression of var2csa translation.
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We can speculate that this isoform could modulate the repression of this set of neuronal genes, in a similar way as G9a dominant-negative designed constructs [ 9].
Some pseudogenes can also compete with their parent genes for microRNA binding, thereby modulating the repression of the functional gene by its cognate miRNA [ 10].
Moreover, Hwangpo et al. indicated the interaction between Spry2 and G protein αo/G protein-regulated inducer of neurite outgrowth (Gαo/GRIN) pathway in modulating Spry2 repression of ERK [ 102].
As external knobs to control the state of the cell, the inducer IPTG modulates the strength of repression of LacI, whereas ATc modulates the strength of repression of TetR.
Another possibility is that DND1 and APOBEC3 function synergistically or antagonistically to modulate miRNA mediated repression of mRNA.
Moreover, these results suggest that PICK1 could modulate the translational repression of endogenous Limk1.
Thus, Brg1 probably modulates PRC2 repression independently of PRC2 recruitment.
MicroRNAs (miRNAs) are non-coding RNAs that modulate gene expression through translational repression of specific target genes [ 11].
The interaction of NMNAT-1 with the eNoSC is responsible for the establishment of heterochromatin by modulating H3K9 dimethylation and subsequent repression of rDNA transcription.
This targeting can induce transcript cleavage, degradation, destabilization, or repression of translation, thereby modulating protein levels.
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