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Consequently, using differentiated IPEC-1 cells, we investigated in this report whether Sc modulates gene expressions and signaling pathways involved in inflammation, recruitment and activation of immune cells.
We first selected RA for our studies, since it directly modulates gene expressions following its binding to RAR or RXR receptors.
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MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability.
Huang S, Wu S, Ding J, et al. MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions.
Jiang W, Bhagat L, Yu D, Kandimalla ER, Agrawal S. IMO-3100, an antagonist of Toll-like receptors 7 and 9, modulates gene expression and regulatory networks induced by ligands.
Researchers used synthetic operons to systematically examine whether the number, length, or order of the genes in an operon modulates gene expression.
It is also known from cell culture studies that SUMOylation modulates gene expression.
Beta-catenin is thought to mediate cell fate specification events by localizing to the nucleus where it modulates gene expression.
MicroRNAs (miRNA) are small endogenously transcribed regulatory RNA which modulates gene expression at a post transcriptional level.
As a nucleocytoplasmic shuttle protein, nucleolin binds to transcription factors and modulates gene expression during differentiation.
These studies demonstrate that chitin modulates gene expression of pattern recognition receptors, in particular TLR4.
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