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These data demonstrate that compound 1 modulates dopaminergic function as determined by effects upon extracellular dopamine responses.
This reduction, however, does not appear to be caused by a direct impairment of the dopaminergic neurons or postsynaptic receptors themselves (Weiss et al, 1996; Cabib et al, 1998; Ossowska et al, 2001; Herman et al, 1984; Zebrowska-Lupina et al, 1988), but may occur instead in an afferent system that modulates dopaminergic function.
The COMT (catechol-O-methyltransferase) gene Val108/158Met polymorphism modulates dopaminergic function in frontostriatal circuitry, and may impact information processing efficiency, due to its critical role in the enzymatic degradation of dopamine.
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Other factors, including perhaps some other metals, most probably also contribute to modulate dopaminergic function and serum prolactin levels.
Thus altering NET expression significantly modulates midbrain dopaminergic function, an effect that may be an important component of the actions of antidepressants and psychostimulants.
These data are consistent with the hypothesis formulated from studies of non-human primates that dihydrexidine and other D1 agonists may be able to modulate prefrontal dopaminergic function.
However, it is possible that the effects of dopamine on valuation are not limited to future events and that enhanced dopaminergic function during imagination modulates the present value of a stimulus, an idea best tested with stimuli that can be directly experienced or consumed.
An enhancement of dopaminergic function could in principle directly modulate incentive salience or alternatively enhance the predicted hedonic utility associated with the vacation destinations, which in turn could boost incentive salience.
Mesocortical dopaminergic function and human cognition.
Altered prefrontal dopaminergic function in chronic recreational ketamine users.
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia.
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