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P38 modulates cell proliferation, controls cell survival and decides cell fate during differentiation.
The results show that extracellular thiol/disulfide redox state modulates cell proliferation rate and that this control interacts with growth factor signaling apparently independently of cellular glutathione.
These recent data show for the first time that PiT1, in addition to its retrovirus receptor and Na+-Pi cotransporter functions, modulates cell proliferation in vitro.
In addition, we also found target genes that are part of a recently described AS transcriptome database [29] such as Wsb1, a SHH regulated E3 ubiquitin ligase, which modulates cell proliferation, viability and stress responses [30] and may be involved in mediating the increased proliferative activity observed in activated ASs [31].
These results suggest that TGFBI modulates cell proliferation and neoplastic transformation phenotypes.
Heparan sulphate proteoglycan syndecan-1 modulates cell proliferation, adhesion, migration and angiogenesis.
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In particular, Fiaccavento et al. have demonstrated that supplementation of dystrophic UM-X7.1 hamsters, carrying a phenotype similar to limb girdle muscular dystrophy 2F (LGMD2F) with ALA, precludes myocyte and muscular tissue damage and modulates cells proliferation promoting myogenic differentiation.
The expression of p53 and p21 proteins is crucial to cell cycle control, and tumor suppressor genes including these can modulate cell proliferation by modulating cell cycle progression [ 13].
Contradictory findings from various cell culture systems support the view that EpCAM expression can modulate cell proliferation, differentiation and migration, but the outcome of modulation is strongly dependent on cell type and origin [ 16- 18].
For example, VCAN is known to favor homeostasis of extracellular matrix, thereby modulating cell proliferation and differentiation15.
The Hippo pathway regulates organ size and cancer formation by modulating cell proliferation and death via regulation of YAP activation12,13,14,15,16.
More suggestions(16)
modulates cell division
modulates differentiation proliferation
modulates cell dissociation
modulates cell response
modulates cell viability
modulates cell invasion
modulates cell motility
modulates cell apoptosis
modulates cell growth
modulates cell adhesion
modulates survival proliferation
modulates cell death
modulates destabilization proliferation
modulates cell morphology
modulates cell surface
modulates cell survival
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