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The enzyme modulates cell motility and plays an important role in tumour invasion and proliferation.
The mechanisms whereby S100A4 modulates cell motility are unknown.
The actin binding protein CapG modulates cell motility by interacting with the cytoskeleton.
Deregulation of actin cytoskeletons caused by weakened cell adhesion directly modulates cell motility, proliferation, and death, providing a molecular basis for the histologic changes in prostate tumorigenesis.
As an example the interaction of the SH3 domain of p130Cas with a proline rich motif in PTPN12 [34] favors its dephosphorylation by PTPN12 and by this mechanism modulates cell motility [35].
Although it does not possess an Arginine Glutamate Aspartate (RGD) domain, a classical structural element for binding to integrins, POSTN also been reported to bind to αV β5 and αV β3 integrins to coactivate EGFR signalling that modulates cell motility and proliferation (Yan and Shao, 2006).
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Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth.
Four and a half LIM domain protein-2 (FHL2) is part of the focal adhesion structures modulating cell motility.
Manipulations that change the stiffness of these 3D scaffolds often alter other matrix parameters that can modulate cell motility independently or synergistically, making observations less predictive of how cells behave when migrating in 3D.
Dysregulation of Src has been linked to oncogenesis process for many years [52], and it is also known to play a role in metastasis by modulating cell motility and invasive abilities in skin, breast and colon cancers [53].
Recently, it has been demonstrated that the tumor suppression function of p27 resides not only in the ability to inhibit Cyclins/CDKs complexes through its N-terminal domain but also in the capacity to modulate cell motility through its C-terminal portion.
More suggestions(15)
modulates cell surface
modulates cell morphology
modulates cell survival
modulates cell dissociation
modulates cell polarity
modulates cell migration
modulates cell behavior
modulates cell cycle
modulates cell proliferation
modulates cell differentiation
modulates cell fate
modulates cell response
modulates cell invasion
modulates cell viability
modulates cell growth
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