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LASP-1 knock out mice exhibit enhanced wound healing and rapid tumor initiation, consistent with the idea that LASP-1 modulates cell migration [47].
Ng and coworkers reported that STAT3 interacts with stathmin and modulates cell migration and microtubule dynamics [ 64].
However, paradoxically, TGF- β1 also modulates cell migration, invasion, angiogenesis, and the microenvironment in ways that cancer cells may exploit to their advantage.
In addition to neuronal migration via reelin, in vitro studies revealed that the VLDLR modulates cell migration via a pathway that depends on uPA [ 10].
αvβ3 Integrin expressed on endothelial cells modulates cell migration and survival during angiogenesis, whereas αvβ3 integrin expressed on carcinoma cells potentiates metastasis by facilitating invasion and movement across blood vessels.
PTEN modulates cell migration of mesoderm cells in the chick embryo through at least two distinct mechanisms: controlling EMT, which involves its protein phosphatase activity; and controlling the directional motility of mesoderm cells, through its lipid phosphatase activity.
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It has been shown that HSPGs may modulate cell migration by interacting with growth factors or chemokines and drives cell migrate toward specific stimuli [ 44].
Through this latter mechanism, SMARCA4 may serve to modulate cell migration and reduce the potential for invasion.
Also microbial factors like phospholipase C and LPS have been found to modulate cell migration (Firth et al. 1997; Häkkinen et al. 2000; Koff et al. 2006).
Integrins play a key role in angiogenesis and tumor metastasis by mediating tumor cell invasion and movement across blood vessel, whereas integrins expressed on endothelial cells modulate cell migration and survival during the angiogenic cascade.
The ability of p27 to modulate cell migration has been previously ascribed by its ability to bind other proteins more directly implicated in the regulation of cellular motility, namely RhoA and stathmin [17], [19] [21].
More suggestions(16)
modulates cell death
modulates cell elongation
modulates cell division
modulates cell surface
modulates cell morphology
modulates cell survival
modulates cell dissociation
modulates cell polarity
modulates cell behavior
modulates cell cycle
modulates cell proliferation
modulates cell differentiation
modulates cell response
modulates cell fate
modulates cell invasion
modulates cell viability
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