Sentence examples for modulates cell fate from inspiring English sources

As a result, it modulates cell fate decision by p53 in response to DNA damage differently according to the extent of DNA damage.

We demonstrate that microenvironment modulates cell fate and subsequent tissue formation during ESC differentiation.

Although it is clear that Ca2 + exerts chemopreventive features in the colon, the molecular mechanisms by which extracellular Ca2 + modulates cell fate are not fully understood.

Our data indicate that PRAP1 modulates cell fate downstream of p53 activation by DNA-damaging agents and suggest that PRAP1 may be an important determinant of cancer cell survival.

For example, the p400 E1A-associated protein, which inhibits p53-dependent p21/waf1 transcription [ 37], modulates cell fate decisions (cell cycle progression, apoptosis, or senescence) by the regulation of ROS homeostasis [ 38].

Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J. Modulating Cell Fate as a Therapeutic Strategy.

The problem of modulating cell fate programs to create distinct patterns and distributions of specialized cell types in different tissues is common to complex multicellular organisms.

It is well known that topographical and biochemical signals play crucial roles in modulating cell fate commitment.

Thus, a coordinated network of post-transcriptional modification pathways may ultimately modulate cell fate determination or stress by coordinating the mRNA stability, translation efficiency and splicing of transcripts that maintain the cell type-specific proteome.

Since acellular lungs from mice with bleomycin-induced fibrosis present considerable micromechanical inhomogeneity, this model can be a useful tool to better investigate how different degrees of extracellular matrix lesion modulate cell fate in the process of organ bioengineering from decellularized lungs.

It is known that nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell cell communication, and modulate cell structure [7, 8].