Substrate stiffness modulates cell differentiation, development, maintenance and regeneration.
CXCL12 modulates T cell development in the thymus [4], [5], T cell adhesion and migration [6], as well as expression of genes controlling T cell signaling, migration and survival [7].
Therefore, one way that sexual differentiation genes might regulate life span is by modulating germ cell development.
Sterol 14-alpha-demethylase is crucial for the production of meiosis-activating sterols, which recently were shown to modulate germ cell development in both sexes of mammals.
Long M, Park SG, Strickland I, Hayden MS, Ghosh S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.
Since BOB1 is involved in both the stimulation of cell division and the establishment of adaxialization, it might act, together with AS2 (as1), as a crucial factor that appropriately modulates cell division and development.
Here, we review these findings and discuss how various signaling pathways and factors function to modulate sensory hair cell development and regeneration.
Mansour A, Anginot A, Mancini SJ, Schiff C, Carle GF, Wakkach A, et al. Osteoclast activity modulates B-cell development in the bone marrow.
Sex steroid hormones also modulate B-cell development and function (Fig. 1A, reviewed in Sakiani et al., 2013).
Together, these results thus strongly suggest that Sox6 facilitates erythroid cell development by modulating the expression of a large panel of marker genes.
