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Inhibition of p38 selectively modulates cell death in infected cells following stimulation with CD3/CD28.
Magnone, M. C. et al. The mammalian circadian clock gene per2 modulates cell death in response to oxidative stress.
During infection by Xcv, the virulence factor FILAMENTOUS HAEMAGGLUTININ ADHESIN 1 (Fha1) targets CaHIR1 where it modulates cell death and suppresses pepper PR gene expression (Choi et al. 2013).
ACD2 modulates cell death in Arabidopsis infected with P. syringae.
It modulates cell death negatively by blocking the apoptotic cascade at different levels.
Collectively, we demonstrate that iron modulates cell death in ovarian cancer cell types in a Ras- and MAPK-dependent manner.
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Both, BAP1 and p53 regulate transcription and DNA damage/repair responses, modulate cell death programs and coordinate cell metabolism.
We concluded that TNZ is genotoxic, cytotoxic and is able to modulate cell death through apoptotic mechanisms in the experimental design employed.
To test the role of each pathway in modulating cell death, we applied kinase signaling inhibitors and then measured changes in cell death and viral reactivation following 48 hours of CD3/CD28 stimulation.
Disruption of heterodimerizations by small-molecule inhibitors could be used to modulate cell death in both cancer (to increase apoptosis) and degenerative disorders (to decrease apoptosis), and assays are necessary to screen compound libraries.
Here, we demonstrate that the central mechanisms of PEI architecture- and size-dependent perturbations of integrated cellular metabolomics involve destabilization of plasma membrane and mitochondrial membranes with consequences on mitochondrial oxidative phosphorylation (OXPHOS), glycolytic flux and redox homeostasis that ultimately modulate cell death.
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