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Their precise functions remain unclear to date [26], but their ligation modulates cell behavior in a subset-specific manner [27] and seems to participate in the shift of Th pattern observed in T lymphocytes during septic shock [8].
Although thermal stress is known to modulate protein production, the mechanism by which stress modulates cell behavior is unknown.
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Relative specificity, therefore, enables mTORC1 to differentially phosphorylate substrates under the same physiological inputs, which modulates cell behaviors and drug sensitivity.
The ECM relays both biochemical and biophysical cues to and from the cells to modulate cell behavior and function.
Vice versa, the ECM exhibits unique mechanical signatures associated with its fibrous polymer network that can modulate cell behavior.
Polymeric nanofibers display unique mechanical properties, which are useful for modulating cell behavior as well providing adequate strength and tension to the cells seeded into the scaffolds.
Recent trends in scaffold design have focused on materials that can provide appropriate guidance cues for particular cell types to modulate cell behavior.
TSPs are multifunctional and modulate cell behavior during development, wound-healing, immune response, tumor growth and in the homeostasis of adult tissues.
Furthermore, the degree of enzymatic crosslinking of the gelatin-Ph hydrogels could be used to modulate cell behavior and the extent of vascular network formation in vivo.
The 3D structures of collagen, a major component of extracellular matrix, might modulate cell behavior, such as osteoblasts in bone formation.
Objective The interactions between integrins and extracellular matrix proteins are known to modulate cell behavior, and may be involved in regulating cartilage formation and repair.
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