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Recently, we have demonstrated that versican G3 domain binds to b1-introgrin and modulates cell adhesion and apoptosis84.
PLL peptide do not mediate receptor mediated adhesion rather it modulates cell adhesion via non receptor mediated electrostatic binding mechanism [4].
Additionally, PC-1 has been localized to cell-cell junctions where it modulates cell adhesion [14], [15], and at sites of cell-matrix interactions [16].
SPARC is a matricellular protein that modulates cell adhesion and growth and modulates cell-matrix interactions by binding to the extracellular matrix [17].
These data indicate that syndecan-1 modulates cell adhesion to collagen via the α2β1 integrin and suggests that this regulation occurs by controlling the affinity state of the integrin.
This multitude of binding partners may explain the diversity of TSP-1 functions: TSP-1 modulates cell adhesion, migration, proliferation and differentiation regulating processes such as inhibition of angiogenesis (through CD36 and β1- integrin) and stimulation of neutrophil migration [28], [40], [41].
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Furthermore, fascin has been shown to modulate cell adhesion and could therefore also function in the dynamic adhesive changes required for both restitution and crypt fission [ 11].
The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.
They allow modulating cell adhesion, invasion, proliferation and differentiation, prior to the regeneration of biologically functional tissue or natural ECM.
The main focus of our labs has been the investigation of how biophysical cues modulate cell adhesion, proliferation, migration, differentiation, and response to growth factors and drugs within the context of corneal wound healing and glaucoma.
Consistently, several non-apoptotic functions of Caspase-8 have been identified and Caspase-8 has been shown to modulate cell adhesion, migration and to promote tumor progression.
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modulates cell surface
modulates cell morphology
modulates cell survival
modulates keratinocyte adhesion
modulates cell dissociation
modulates cell polarity
modulates cell migration
modulates cell behavior
modulates cell cycle
modulates cell proliferation
modulates cell differentiation
modulates cell response
modulates cell fate
modulates cell viability
modulates cell invasion
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