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In addition, myostatin modulates activation of AMP-activated protein kinase (AMPK) in muscle (59), the key enzyme in a second pathway that plays a role in both muscle metabolism and growth (26, 29).
Proanthocyanidin modulates activation of LXRs [ 9], which are oxysterol-activated nuclear receptors that control cholesterol homeostasis by modifying expression of genes involved in cholesterol absorption and efflux from peripheral tissues.
Paroxetine dose-dependently modulates activation of the entire motor pathway in a way that favors motor output.
Recent evidence suggest that 1,25(OH)2D3 may affect T-dependent responses in cattle; however, mechanisms by which this vitamin modulates activation of bovine T cells are unclear.
Additionally, exposure to Sb before the infection modulates activation of Rac1, MAPK and NF-κB during infection.
In addition to lineage specification, PTP1B modulates activation of monocytes/macrophages.
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Collectively, our data indicates that constitutive hepatocyte COX-2 expression ameliorates NASH and liver fibrosis development in mice by reducing inflammation, oxidative stress and apoptosis and by modulating activation of hepatic stellate cells, respectively, suggesting a possible protective role for COX-2 induction in NASH/NAFLD progression.
On the other hand, the recessive resistance gene xa5 is an allele of the general transcription factors TFIIAγ (Iyer and McCouch 2004), which probably confer resistance by modulating activation of other TALE targets.
Nevertheless, the ability of IL-10 to down-modulate activation of innate immune effector cells such as macrophages suggests that overproduction of this cytokine must be avoided.
In addition, we also explored the extent to which Tat and opiate-induced changes in [Ca2+]i modulate activation of the NF-κB pathway.
Triggering of this receptor down-modulates activation of the γδ TCR and inhibits γδ T cell proliferation and IFN-γ and TNF-α production in response to microbial phosphorylated ligands representing a mechanism to control self-reactivity of γδ T cells.
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