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Although most modulated transcripts in V. vinifera are also modulated in V. riparia, there is a small collection of genes induced specifically in V. vinifera.
The spleen and lung had the highest number of modulated transcripts in common.
Other functional categories each accounted for up to 6% of modulated transcripts in both species at both time-points.
There was a much higher number of modulated transcripts in the 21/66 offspring than in Teroldego and the 22/73 offspring.
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Among the 520 transcripts, 473 were up-modulated and 47 were down-modulated transcripts in ERα tumors.
This demonstrates how modulated transcripts identified in our experiments provide promising candidates for biotechnology-based disease resistance programs.
Red: transcripts increased >twofold; blue: transcripts decreased >twofold; numbers of modulated transcripts are indicated in the corresponding color.
In both lines, the majority of modulated transcripts was up-regulated, although in the susceptible genotype a higher percentage of pathogen-induced genes was detected (~73% vs. ~83% for CO441 and CO354, respectively).
About 7% of the modulated transcripts corresponded to genes involved in transport.
More interesting was the analysis performed after 24 h where differential gene expression analysis revealed 22 modulated transcripts (6 decreased and 16 increased) in TNF-α-stimulated cells compared with controls.
Differential gene expression analysis revealed 510 modulated transcripts (305 decreased and 205 increased) in AP-2α silenced cells compared with controls (see Methods).
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