Sentence examples for modulated towards from inspiring English sources

Furthermore, the primary p53 regulatory circuit is clearly modulated towards p53 activation and pro-apoptotic signaling by E2F1 and E2F3, the one by an up-regulated and the other by a down-regulated mechanism.

Since changing system-level phenomena is difficult, it is important to understand how HRSs emerge and evolve, and can be modulated towards well functioning NHRSs.

The predictive potential of this analysis was based on the finding that the dynamics of gene expression in patients with active disease were modulated towards levels characteristic of healthy controls in proportion to a given individual's response to therapy.

15, 35 In doing this, we also propose that the bimodal activity of IL2 can be harnessed and modulated towards bulk activation of antitumor effector cells to produce a substantial increase in the complete response rate.

We propose that based on the location of the Asn137 glycosylation site within the FGFR-binding interface, glycosylation of FGF8 subfamily members could play a role in modulating affinity towards FGFRs.

Such analysis can assist in producing hypotheses that can explain how the kinome is involved in the maintenance of different cellular states and can be manipulated to modulate cells towards a desired phenotype.

In addition, in vitro studies have demonstrated that B. infantis administration to the gut microbiota modulated gut bacterial populations towards reduced colonic endotoxins concentrations [ 19].

In another study, Eggink et al. (2014) modulated the immune response towards conserved stalk domain by hyperglycosylation of globular head domain which masked the immunodominant region.

Recent studies showed that self-other integration, as indexed by the joint Simon effect (JSE), can be modulated by biasing participants towards particular (integrative vs. exclusive) cognitive-control states.

Gene expression can be modulated in two opposite directions, towards higher or lower amounts of product.

The influence of claims on consumers' perception was modulated by their hedonic sensitivity towards sugar-reduction.