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Further, touch modulated the responsiveness of auditory cortex neurons to ultrasonic vocalizations.
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The pan-TRK receptor p75NTR further modulates the responsiveness of TRK receptors to neurotrophins [22].
Norepinephrine (NE) modulates the responsiveness of macrophages to proinflammatory stimuli through the activation of adrenergic receptors (ARs).
Cellular O-GlcNAc levels respond to environmental and nutrient stress in animal cells, and increasing global levels of O-GlcNAc-modified proteins increases stress tolerance and modulate the responsiveness of cells to extracellular signaling [47].
Prolonged high expression of ALKBH2 also indicates that it may modulate the responsiveness to Ph-PDT.
This suggests that changes of expression and activity levels of the DGC and PDE enzymes due to e.g. transcriptional regulation might modulate the responsiveness of the system.
Also, the data concur with the notion that nociceptive thresholds are not fixed and can be lowered or elevated to modulate the responsiveness of the sensory neurons.
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling and are expressed after cytokine stimulation, directly interacting with JAK/STAT pathway members to modulate the responsiveness of cells to further signaling.
Although the effects of environmental pollutants on drug transporters as well as on metabolic and detoxifying enzymes have been explored to some extent (Brockmoller et al. 2000; Chen et al. 1998; Han and Zhang 2004), there is no information on whether endocrine disruptors can modulate the responsiveness of breast cancer cells to anti-cancer drugs.
Endotoxin hypo-responsiveness is associated with an emergent acquired dynamic state of the system that modulates the response of the system not to respond rigorously to the primary endotoxin challenge.
The present study evaluated the SBA-15 capacity to modulate the immune responsiveness of High and Low responder mice immunized with BSA encapsulated/adsorbed in SBA-15 by the intramuscular or oral route and the adjuvant effect was compared with the responsiveness induced by BSA in aluminum hydroxide salts or emulsified in Incomplete Freund adjuvant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com