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Furthermore, SP-CA116D cells secreted soluble factors into the medium that modulated surface expression of CCR2 or CXCR1 receptors on CD4+ lymphocytes and neutrophils, suggesting a direct paracrine effect of SP-CA116D on neighboring cells in the alveolar space.
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During the course of these studies, we identified subpopulations of SIV-specific T cells that appear to have down-modulated surface expression of CD8 molecules in B cell follicles and in the vaginal and cervical epithelium.
Upon agonistic anti-4-1BB mAb treatment, CD4+ T cells of NP-mice down-modulated surface expression of all activated T cell markers, suggesting a reduced activation of antigen-specific CD4+ T cells following agonistic anti-4-1BB mAb treatment.
Furthermore, down modulated CD4 cell surface expression and subcellular localization [ 18], and depletion of the surface CD4 protein [ 19] have been reported in the literature in some cases of HIV infection.
All cells with down-modulated HLA-ABC surface expression were also eGFP+.
As with CD62L expression, epratuzumab incubation down-modulated β7 integrin surface expression which was again seen primarily on CD27negative B-cells.
Recently, TMEM59 was reported to be a Golgi-localized protein, which is crucial in modulated complex glycosylation, cell surface expression and secretion of amyloid precursor protein [ 34].
However, surface expression of IgD and IgM was not modulated (data not shown); thus, ES-62 does not simply induce anergy resulting from down-regulation of the B cell receptor.
Of note, surface expression of CD62L and β7 integrin was simultaneously down-modulated on B-cells after incubation with epratuzumab.
The surface expression of NKp30L and NKp44L correlates with sensitivity towards NK cell lysis, is sensitive to trypsin treatment and is down-modulated in cells arrested in G2/M phase.
And it was from that concept that her Modulated Surfaces (1955-57) and Planes in Modulated Surfaces (1957-58) series came about.
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