In addition, cation π interactions are frequently observed to zip up the edges of the interface between intertwined chains or to involve hinge loop residues, thereby modulating stability.
The ability of PINK1 to mediate turnover of mitochondrial proteins is not unusual given its role in modulating stability of membrane-bound respiratory chain subunits (Vincow et al., 2013).
Finally, as FMR6 overlaps two microRNA binding sites for miR-19a and miR-19b in the 3′UTR of FMR1 (Edbauer et al. 2010), it is possible that this lncRNA can modulate stability or translational efficiency of FMR1 through interference with microRNA binding.
Moreover, we modulated protein stability throughout the entire trajectory using overexpression of GroEL/ES to avoid evolutionary dead ends caused by stability bottlenecks (Socha and Tokuriki, 2013; Wyganowski et al., 2013).
Finally, tumor necrosis factor alpha (TNFα), a classical activator of NF-κB signaling, modulated the stability of RARα protein.
Therefore, we evaluated and modulated mRNA stability by modifying the 5′ and 3′ UTR characteristics of mRNA.
Although it is unlikely that these AREs modulate stability during shutoff, there may be other attributes common to the escapee subset of ARE-bearing mRNAs, or highly regulated mRNAs in general, that promote escape from SOX-mediated degradation.
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.
Therefore, we subsequently investigated whether cafestol modulates stability of Mcl-1 protein.
Moreover, we tested whether TNFα, a classical activator of NF-κB signaling, modulates stability of RARα protein.
We use molecular dynamics simulation to find the most cleavage-prone arrangement of α chains in a collagen triple helix and find amino acids that modulate stability of the MMP cleavage domain depending on the chain registry within the molecule.
