Sentence examples for modulated primarily by from inspiring English sources

Changes in several of the metabolites were common to both doses, with additional metabolites modulated primarily by the low (80 mg/day) dose.

VSMC proliferation is modulated primarily by regulation of the cell cycle, S-A144 inhibited cell cycle progression by arresting cells in G0/G1 phase.

In animals, it has been suggested that cell size is modulated primarily by the balance of external signals controlling growth and the cell cycle [ 1], although there is evidence of cell-autonomous control in cell cultures [ 6, 7, 8, 9].

Furthermore, the dopaminergic neurons of the VTA also show pacemaking activity, but the activity in these neurons is modulated primarily by sodium with minimal contribution from calcium channels (Khaliq and Bean, 2010).

IP3Rs can be modulated primarily by IP3 and Ca2+ itself; the latter can also regulate IP3Rs indirectly through calmodulin (CaM); other modulators include phosphorylation by Ca2+/CaM-dependent kinase II (CaMKII), cGMP-dependent protein kinase (PKG), protein kinase C (PKC), and cAMP-dependent protein kinase (protein kinase A, PKA).

These studies correlate with our findings and suggest that the co-infected PBMC protein profile is dominated by the proteins modulated primarily by HCV infection and that the similarity in the liver disease abnormalities in this patient population is due to the presence of HCV co-infection.

However, the model for σB regulation established in B. subtilis suggests that σB activity in L. monocytogenes is modulated primarily at the posttranslational level by a partner switching mechanism [ 26].

It was suggested by Zheng et al. [ 35] that endogenous LC-PUFA biosynthesis was regulated by nutritional factors that modulated primarily the expression of fatty acyl desaturases, but not the elongases.

miR-34a, in turn, was modulated primarily beyond the third day of differentiation.

78 miRNAs are another important class of gene expression regulators that modulate (primarily downregulate) expression of target genes either by inhibiting translation or promoting mRNA degradation.

Third, while LV modulates FU by enhancing its anti-DNA effects via the inhibition of thymidylate synthase, MTX modulates FU primarily by increasing the incorporation of fluorouracil triphosphate into RNA, adding pharmacodynamic interest to the comparison (Sobrero et al, 1997).